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Long-term lymphocytic leukemia (CLL) is a lymphoid malignancy characterized via the proliferation and accumulation of mature CD5+ B cells from the blood, bone marrow and lymphoid tissues. The diagnosis of CLL involves the existence of ≥five x109/L mono - clonal B cells of regular phenotype during the blood.
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mutations and complicated kar yotype. It follows a linear evolution through the CLL clone with the recurrent acquisition of CDKN2A
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